I Stephan, Thank you. Is 1.57 L the fluid volume ? of the total volume (empty and full) ?; it is high, BCS/DCS classification assume 250 mL and now 500 mL in total, with about 250 mL as water administration volume. Can grey area be changed? Regards Xavier. De : esqlabs GmbH ***@***.***> Envoyé : mercredi 5 mai 2021 16:10 À : Open-Systems-Pharmacology/Forum ***@***.***> Cc : Xavier Boulenc ***@***.***>; Author ***@***.***> Objet : Re: [Open-Systems-Pharmacology/Forum] Physiological fluid volume in the gut (#728) Sorry, my misunderstanding... You can change this via the fraction of stomach volume filled with liquid ... the parameter is called "Fractional steady state fill level": It can be found here: [image]<https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fuser%2dimages.githubusercontent.com%2f25477643%2f117154525%2d3768bd00%2dadbc%2d11eb%2d9cce%2de62cb6b1e8d1.png&umid=47bf53b8-77f0-4f5d-8c64-6733832f9589&auth=670e6529b563b7dbb42ee90dda0d50ae13dc637b-613bfa7842c76f9d7b2b5615d9b34d5b5a74687b> — You are receiving this because you authored the thread. Reply to this email directly, view it on GitHub<https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fgithub.com%2fOpen%2dSystems%2dPharmacology%2fForum%2fissues%2f728%23issuecomment%2d832718675&umid=47bf53b8-77f0-4f5d-8c64-6733832f9589&auth=670e6529b563b7dbb42ee90dda0d50ae13dc637b-46a65f0f40f44f4a72ba0d05f73fdb0dcf9e28f2>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AQ72QA7NN3RVSKAHZXXBXXTTMFGRVANCNFSM44EYMHBA>. Veuillez trouver notre information relative à la protection des données ici<https://www.evotec.com/en/about/site-information/data-protection-fr> STATEMENT OF CONFIDENTIALITY. This email and any attachments may contain confidential, proprietary, privileged and/or private information. If received in error, please notify us immediately by reply email and then delete this email and any attachments from your system. Thank you.

Hi Stephan, My turn of misunderstanding ☺ Clear ; thank you for your help. Regards. Xavier. De : esqlabs GmbH ***@***.***> Envoyé : mercredi 5 mai 2021 17:14 À : Open-Systems-Pharmacology/Forum ***@***.***> Cc : Xavier Boulenc ***@***.***>; Author ***@***.***> Objet : Re: [Open-Systems-Pharmacology/Forum] Physiological fluid volume in the gut (#728) Hi Xavier, no, this is the luminal volume of a "full" stomach. Liquid volume is "Fractional steady state fill level" multiplied with this "Volume" .. so around 50 ml? This would be the liquid volume in a fasted state. What the is added with the oral administration comes on top. Best, Stephan — You are receiving this because you authored the thread. Reply to this email directly, view it on GitHub<https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fgithub.com%2fOpen%2dSystems%2dPharmacology%2fForum%2fissues%2f728%23issuecomment%2d832769998&umid=aa132d9d-5814-47af-9f84-f461848fa84a&auth=670e6529b563b7dbb42ee90dda0d50ae13dc637b-decdc912918a38edee1366af2def829f50086814>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AQ72QAYOHZBUYUGHA6ZYXLTTMFOCNANCNFSM44EYMHBA>. Veuillez trouver notre information relative à la protection des données ici<https://www.evotec.com/en/about/site-information/data-protection-fr> STATEMENT OF CONFIDENTIALITY. This email and any attachments may contain confidential, proprietary, privileged and/or private information. If received in error, please notify us immediately by reply email and then delete this email and any attachments from your system. Thank you.